The Lobe (voiced by David Warner) – Freakazoid's archenemy. He is a super genius whose entire head appears to be a giant brain. Despite his high intellect, he has very low self-esteem, once even having a scheme foiled by Freakazoid simply insulting the plan, despite actually being impressed by it. No background information of any kind is given for The Lobe; not even his real name is revealed.
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